As the saying goes, “beauty is only skin deep,” — and Perricone MD agrees.  

More than two decades ago, the brand launched its three-tiered skincare and wellness systems, which go beyond topical treatments. The founder, Dr. Nicholas Perricone, MD, applied his knowledge and expertise to formulate solutions to revitalize skin through diet, vitamin supplements, and skincare products.

Packed with premium ingredients, topical application of the skincare treatments brings various benefits, not limited to fighting skin aging and dark circles. At the same time, adding the goodness of supplement powders from the brand can accelerate the effects of each high-quality formula. 

And the best part? Every product is dermatologically-tested for safety and has the seal of approval from many satisfied customers. So, check out our selection and full reviews of the best Perricone MD products and unlock the secret to healthy skin today. 

Top 10 Perricone MD Products

1. High Potency Classics: Face Finishing And Firming Moisturizer

The High Potency Classics Perricone MD range was designed to fight skin aging with its power-packed formulas backed by science. And the bestselling Perricone MD moisturizer from the skincare line is considered a classic for many reasons. Simply put, it offers anti-aging properties and leaves the skin plump and hydrated. 

Here, the blend of industry staples, including DMAE and alpha-lipoic acid, improves skin firmness to decrease the appearance of fine lines and wrinkles. At the same time, the addition of rich antioxidants and the patented Vitamin C Ester impart a radiant glow. All you need to do is apply a liberal amount of the product in the morning and evening for the best results. 


The absence of SPF protection keeps this formula from becoming a comprehensive day cream. 


This firming moisturizer finds a permanent place in the hearts and cabinets of those looking for an ideal solution for sagging skin and building skin elasticity. Most users have also mentioned that the product leaves a light yet lingering rose scent that adds to its charm.  

2. Vitamin C Ester Brightening Amine Face Lift

Finish your morning and evening routines with the Perricone MD Vitamin C Ester serum that works to give you an instant facelift. Apart from the skin-tightening properties that make it an excellent anti-aging skin care product, the brightening serum works to reduce dark spots to correct uneven skin tone. The manufacturer recommends massaging the lifting serum onto the face and neck using an upward motion after cleansing. 

Here, the addition of nourishing ingredients, supercharged with the innovative vitamin C ester, creates a gentle micro-exfoliation technology. While the dermatological benefits of vitamin C[1] are already known, the makers have fine-tuned the ingredient for smoothening effects that won’t irritate sensitive skin. 


Users will need to apply a suitable sunscreen over the product during the day, as it contains alpha hydroxy acid (AHA), which increases skin sensitivity to the sun. 


While rich antioxidants in the Vitamin C Ester Brightening Serum support an even skin tone, the addition of copper complex[2] provides gentle exfoliation for better skin elasticity. Not to mention, the lightweight formula is easy to apply and quickly absorbs into the skin for a tighter and youthful complexion. 

3. Cold Plasma Plus+ 

Common signs of aging are rarely limited to the face, with wrinkles often spreading over to the neck and chest region. With that in mind, the Perricone MD Cold Plasma Plus+ cream has been designed to target all these problem areas. And as users massage the product onto the entire upper-chest area and move up to the face, it leaves a therapeutic effect while also firming skin with supercharged ingredients. 

This beneficial blend includes vitamin C ester, peptides, vitamin B3, and, most notably — broad-spectrum SPF 25. The addition of sun protection reduces the risk of cancer while also undoing the effects of sun damage or, perhaps, years on the tanning bed. In other words, it doubles as a sunscreen that prevents sunburn and corrects sun damage-related uneven skin tone and aging. 


Considering how users should apply the cream liberally for the best results, one jar may run out in a few weeks, making it an expensive product.


The most visible benefit of this cream is its tightening properties, with many users noticing supple skin and reduced crepiness around the chest and neck. It is worth noting that these benefits were closely-related to the correction of sun damage and cellular rejuvenation. 

4. Hypoallergenic Firming Eye Cream

Another wrinkle cure formulated by the brand, this eye cream centers around olive polyphenols, a natural ingredient that can revitalize the sensitive skin around your eyes[3]. The pure and potent blend is dermatologically-tested and offers a safe and hypoallergenic solution for diminishing eye bags, dark circles, and crow’s feet. 

Despite its rich texture and hydrating properties, the nourishing and lightweight cream is non-comedogenic and won’t block pores. So, whether you have oily or very sensitive skin, the natural oils provide a restrained yet effective solution for building skin firmness. 


The premium product comes at a steep price for a relatively small amount. 


This nourishing eye cream strikes the right balance, offering a smooth texture that is lightweight and hydrating — all at once. Also, the product gets absorbed quickly and does not leave any residue, ensuring a comfortable feeling throughout the day.

5. High Potency Classics: Hyaluronic Intensive Moisturizer 

The Classic collection from Perricone MD has been fine-tuned to address wrinkles and other signs of aging. And if you’re a fan of the lightweight texture of products from the skincare line, you’re bound to love this oil-free moisturizer. The indulgent face cream infuses the goodness of three forms of hyaluronic acid[4] for a deep-moisturizing effect without leaving a greasy feeling. 

At the same time, the blend includes DMAE and rosemary leaf extract to tighten the skin for a plump and youthful texture free of wrinkles. Gently massage the product on the face and neck twice a day, and you should see visible improvements in a few weeks.  


As it is not a completely fragrance-free product, some users may be sensitive to the overpowering smell upon application. 


The oil-free product infuses hyaluronic acid, which acts as a gentle lubricant that smoothes out wrinkles for a youthful look. With regular application, you can expect fewer fine lines and wrinkles in a few weeks. 

6. Neuropeptide Firming Moisturizer

The brand launched the relatively younger Neuropeptide collection after rigorous research over 20 years. Each product from the advanced line is infused with ingredients that support collagen production to promote healthy skin and fight signs of aging. And indeed, the Neuropeptide Firming Moisturizer may be just what you need for a dramatic decrease in sagging skin. 

Formulated from amino acids and ultra-rich neuropeptides, the product has a creamy consistency that provides instant hydration for everyday use. And upon regular application, customers have noticed visible improvements in skin tone and texture. 


While the moisturizer contains hydrating properties, it may not be an effective emollient for dry skin or normal skin during dry weather. 


The luxurious and creamy texture feels soft and gentle on the skin but does not leave any residue or greasiness. However, the highlight of the product is its ability to fight the signs of aging even when used as a daily moisturizer. 

7. Neuropeptide Night Cream

Deep-set wrinkles may seem like a lost cause — but not anymore with this advanced night cream. In fact, the neuropeptide-rich formula targets four types of deep lines and wrinkles, including gravitational, static, and dynamic wrinkles. So, whether you want to zap away nasolabial folds or marionette lines, this wrinkle cream could be your cure-all.  

We recommend following the manufacturer’s instructions and massaging the product using an upward motion after cleansing. It is also worth mentioning that the Neuropeptide collection targets the neck, face, eyes, and chest, so don’t forget to apply the product to these problem areas.   


The thick consistency of the product works like a rich serum rather than a light moisturizer. 


This rich and smooth night cream has a buttery texture and works overnight to replenish skin cells and diminish stubborn wrinkles and fine lines. Simply put, it lives up to its reputation as an advanced anti-aging product.

8. No Makeup Blush

The natural “no-makeup” makeup look is all the rage today. Perricone MD takes the trend to the next level with this innovative product that is so lightweight that you may not even feel it. Aptly named the “No-Makeup Blush,” the sheer formula tints the cheeks for a natural-looking pink flush. What’s more, the blush is blendable and buildable, allowing users to fuse it with the skin while applying other products effortlessly.

Just remember to apply the product on the cheekbones to accentuate your features and pat it in an upward motion while blending. 


Many customers have mentioned that the flimsy bottle cap breaks easily and should be handled with care while transporting. 


The peachy-coral hue is ideal for a natural makeup look suitable for all seasons. Moreover, the small applicator allows users to control whether they want a minimal or more pronounced look fit for other occasions. 

9. Vitamin C Ester Brightening Cleanser

No skincare regimen is complete without a cleanser — and if in doubt about which to pick, you can always go for the Perricone MD Vitamin C Ester Brightening Cleanser. After all, this gentle, non-drying face wash has been formulated for all skin types. So, whether you have normal or dry skin, the proprietary vitamin C ester ensures that your skin is not stripped of its natural oils. 

At the same time, the potent blend is packed with DMAE and citrus-based ingredients that can balance oily T-zones and other problem areas. Nevertheless, the product is suitable for everyday use; remember to lather a quarter-sized amount over damp skin for the best results. 


Since the product is high in acidic content, you may experience a burning sensation if it comes in contact with your eyes. 


This gel-cleanser is packed with energizing ingredients that will instantly brighten your skin and leave a calming sensation. Apart from daily hydration, continued use can help you lighten dark spots and improve clarity. 

10. No Makeup Foundation Serum

Like many other Perricone MD products, this formula multi-tasks and works as a serum and foundation — all at once. First off, the semi-matte texture provides buildable coverage and is available in eight shades to suit your skin tone. And while its cosmetic properties offer a temporary solution for skin imperfections, the blend doubles as a serum to eliminate wrinkles and fine lines. 

Upon a closer look, you will find that the formula contains natural ingredients, including daisy flower extracts and bisabolol, for their brightening qualities. The serum is then finished off with a broad-spectrum SPF 20 for protection against sun damage. 


The foundation may not blend with makeup products from other brands. 


With this skincare-infused makeup foundation, you can expect adequate coverage for deep lines, acne scars, and blemishes. The makeup product then works overtime as a sunscreen and a serum to eliminate skin imperfections for good.

What Are The Key Ingredients In Perricone MD Products?

Perricone MD is transparent about all the ingredients in each formula and even offers hypoallergenic products for those with normal to very sensitive skin. Each of the skincare solutions is cruelty-free and mostly relies on the goodness of natural ingredients, including:

1. Vitamin C Ester

Vitamin C ester, a patented ingredient from the brand, is a less-abrasive form of vitamin C that retains its antioxidant properties for skin brightening. Rest assured this derivative works, unlike other citrus-based ingredients that tend to strip skin of its natural oils and may be too harsh on sensitive skin. Apart from offering a solution for delicate skin, vitamin C ester may help slow down the aging process by stimulating collagen synthesis[5]. 

2. Neuropeptides

Neuropeptides, when applied topically, may help fight signs of aging, including fine lines and wrinkles[6]. The cosmetic uses of this ingredient as a wrinkle cure are closely associated with its ability to influence facial contractions, cellular proliferation, and other skin-related processes. In fact, some liken its effects to botox, sans the risks of immobilizing facial skin.


Clinical studies have found that dimethylaminoethanol(DMAE) when used as a serum, can help prevent issues related to aging skin[7]. From reducing fine lines around the eyes to frown lines on the forehead, users may see visible improvements after continued use for about 16 weeks. 

4. Vitamin E and Vitamin F

Vitamin E from plant-based sources, such as olives, provide intense hydration and moisturization to maintain skin health and a bright look. Similarly, vitamin F is a rich source of natural fats and is often found in seeds, including flaxseed, pumpkin seed, etc. These natural oils repair and rejuvenate the skin’s moisture barrier for a long-lasting youthful glow.

5. Hyaluronic Acid

Hyaluronic acid is an industry staple that has been tried and tested for its water-retention capacity. To understand the science behind how it works, you must keep in mind that well-hydrated skin refers to skin with a lot of water content. 

Here, hyaluronic acid acts as a humectant that binds up to 1000 times its weight in water. The ingredient simultaneously prevents transepidermal water loss or the evaporation of water from the skin. As a result, your skin remains hydrated and moisturized for longer. 

Are Perricone MD Products Worth It?

Perricone MD has remained an industry favorite for over two decades and has raked in thousands upon thousands of glowing reviews from all over the world. It is worth noting that the brand was recently acquired by The Hut Group and has undergone several changes.

Nevertheless, customers have mentioned that Perricone MD has retained its signature dedication to science-backed solutions and premium quality even after rebranding. The brand recently launched its advanced anti-aging skincare line centered around neuropeptides and has received mostly positive feedback. 

At the same time, the High Potency Classic collection still boasts a loyal fanbase and remains a go-to for those looking for effective wrinkle cures. All in all, the products are suitable for all skin types but work best if you are looking for anti-aging solutions. 

When it comes to pricing, MD Perricone leans towards the more expensive side of things, with most products priced similar to skincare solutions from premium high-end brands. But considering how each formula has been researched and fine-tuned to offer multiple benefits, you get a bang for your buck. 

Where Can I Buy Perricone MD Products?

Perricone MD skincare products are available on the official website and various e-commerce platforms. If you’re buying from a third-party seller, ensure that it is a trustworthy site or offline source to avoid inferior duplicates with questionable ingredients or used products. 

Some trustworthy retailers include Sephora, Walmart, Ulta Beauty, Nordstrom, and Skinstore. For online stores, always go through the customer reviews before finalizing a purchase to be on the safe side.

What Are The Benefits Of Perricone MD Products?

This dermatologist-founded brand prides itself on formulating products based on cutting-edge research using clinically-tested ingredients. Rest assured, each Perricone MD product is safe for use, and each component is included to provide specific benefits. 

In fact, some of these are high-performance multi-tasking formulas that provide relief for common skin concerns, such as dry skin, enlarged pores, and aging skin — all at once. Here’s a rundown of the benefits that have made Perricone MD products worth their price:

1. Anti-Aging

Most bestsellers from the company have been designed to fight signs of aging and are well-suited for sensitive and mature skin. These include products from the Classic and Neuropeptide collections that are brimming with antioxidants and power-packed ingredients, such as DMAE and alpha-lipoic acid.

As a result of the potent blends, many customers have noticed visible improvements in sagging skin and wrinkles around the face, neck, and upper chest area.

2. Hydration

Hyaluronic acid and other naturally-derived fats act as moisturizing elements that find their way into most formulas from the company. Thes ingredients provide intense hydration and are added in careful concentrations to avoid any residue or greasiness. On that note, the moisturizers, night creams, and other hydrating options from the brand are lightweight and easily absorbed into the skin. 

3. Skincare-Infused Makeup

It is worth noting that Perricone MD products seldom provide solutions to a single skin-related issue. So, whether your choice of skincare treatment aims to reduce wrinkles or dark spots, the ingredients in the formula work with a two-pronged action. 

For instance, vitamin C ester, a common ingredient in many Perricone MD blends, is a powerful antioxidant that helps to maintain an even and bright skin tone. At the same time, it lends anti-aging properties to zap away fine lines and other skin imperfections. 

Similarly, Perricone MD offers innovative skincare-infused makeup products, including foundations and blushes, that simultaneously boost skin health in various ways. 


Dermatologists undergo rigorous training and schooling to identify ingredients that are best for the skin. Considering how Perricone MD is a dermatologist-founded skincare line, you can rest assured that each formula is effective at best — and safe at worst. 

While a personalized consultation is the best way to go, Perricone MD offers various restrained and well-researched formulas well-suited for all skin types. Furthermore, the brand has fine-tuned several skincare lines for common issues, such as acne, aging skin, sensitive skin, and so on. 

Regardless of the range you go for, the lightweight products from the brand are gentle on delicate skin and potent enough to eliminate oiliness. And whether you need a product to fight wrinkles or inflammation, we recommend combining your skincare routine with a healthy diet and dietary supplements from Dr. Perricone for accelerated results. 









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