If you’re here, we’re sure the hustle of everyday life has made you think seriously about starting with an antioxidant-rich health supplement.
And we’d say you’ve made a good decision to look up glutathione — it’s one of the most sought-after supplements on the market for its superior antioxidative effects. It occurs naturally in several body organs, including the lungs, heart, liver, and kidney, so a good-quality supplement of the compound is practically harmless for your system.
But we understand the challenge lies in choosing a product that will offer the goodness of genuinely effective, all-natural glutathione. That’s why we’ve decided to pen this detailed guide to the best glutathione supplements on the block.
We’ll also help you develop a clear idea about glutathione and its properties. That way, you can be more confident about incorporating the supplement into your daily routine.
So, without further ado, let’s get started!
Best Glutathione Products and Brands
First off, here’s a powerful supplement from Bulletproof that uses a potent formula to promote maximum glutathione absorption by your body. The Glutathione Force capsules utilize a liposomal delivery system that transmits this master antioxidant to the small intestine for effective absorption and use. As such, it helps your system get rid of lots of toxins, ensuring your body cells function optimally.
This intensive cleansing process boosts your immune system and makes the body equipped to handle the stress of day-to-day living. Also, the gluten-free, non-GMO, and vegan formulation of this supplement rules out the chances of any adverse reaction. It’s even naturally sugar-free, so rest assured your diet won’t be hampered while you’re on a detox regime.
For some users, this supplement might take a few months to show substantial results.
The superior liposomal delivery system combined with an all-natural formulation makes these liposomal Glutathione capsules stand out among many others. Ultimately, you get a more intense detoxifying action that helps reduce stress and energizes the body adequately.
This acetylated supplement is another dependable option as it provides a similar boost in the cellular absorption of glutathione. It comes in the form of potent magnesium and acetyl-glutathione capsules that help maintain body balance apart from promoting detoxification. The acetylated form makes this supplement a powerful chelator of heavy metals and rids the body of other harmful toxins alongside.
Also, its composition is devoid of gluten, dairy products, and artificial preservatives and flavors. That’s why you need not worry about major side effects or unsatisfactory results. In fact, the formulation is third-party lab tested for potency and purity, which sets it apart from other products in terms of reliability. The brand even offers a refund guarantee, which reflects its confidence in the product.
When it comes to enhancing mental alertness, the detoxifying action of this supplement may not be as helpful as other similar options.
This acetyl-glutathione supplement works wonders in eliminating toxins in your gut and improving energy levels for better productivity. As such, it’s an ideal choice if you’re in search of a remedy for digestive issues or an all-natural energy booster.
Halfway through our list, we’ve picked a liposomal glutathione liquid that enhances the ability of your system to process and recycle the antioxidant. It utilizes liposomal delivery to increase absorption of the active, reduced form of glutathione. Plus, the formulation has other vital ingredients such as Riboflavin, Molybdenum, Selenium, and PQQ that support the function and recycling of glutathione.
All the components combine to initiate a healthy detoxification process and support physical activities, making you feel energized and rejuvenated from within. They may also help support liver health and prevent skin disorders by reducing free radicals in the body. Plus, all its ingredients are sourced and tested carefully to ensure the complete safety of users — they’re 100% vegan and gluten-free.
The liquid gives out a strong smell of Vitamin B, which might seem disturbing to some users.
We’d strongly recommend this supplement if you’re looking for all-natural solutions to improve your liver health. Another great advantage is that it’s among the few products that can reduce the excess oxidation often associated with the production of glutathione.
Pure Encapsulations is among the most trusted health supplement brands, utilizing premium-quality ingredients and extensively researched formulations for all its products. The glutathione capsules are no different, as they use two high-quality blends of the antioxidant and several phospholipids to enable intense liver detoxification. Moreover, they support and protect cellular function in the long term.
Do note that this formulation is free from dairy ingredients and artificial additives like the other options on our list. Plus, it’s manufactured based on strict quality standards and extensively tested for purity and potency.
It’s priced higher than several other options coming with equally potent formulations.
Containing 600 mg of glutathione per serving, this supplement is among the purest and most potent detox systems you’ll find on the market. Its all-around detoxification process helps improve your overall health considerably in the long term.
Next up is a liquified supplement from Quicksilver that’s specially formulated to promote rapid uptake of glutathione for faster detoxification. It uses an advanced phospholipid delivery system to transfer the core ingredients to body cells effectively. Do note that the formulation comprises reduced glutathione particles that resist breakdown by stomach acids to promote efficient intracellular absorption.
Moreover, every 1 ml of the liquid delivers a commendable 100 mg of glutathione to provide maximum potency. And in addition to the intense detoxifying effect, it also provides increased energy levels, better immunity, and long-lasting antioxidant protection. The liquid even has a lemon mint essence that feels pleasant to the taste buds.
Though the brand claims this liquid is delivered at a low temperature to ensure the best results, some customers reported it was much warmer.
The use of an advanced glutathione formulation comprising reduced particles enhances its efficiency substantially. Plus, you’ll never feel reluctant to take the dosage, thanks to the refreshing lemon and mint essence on offer.
Next, let’s talk about this powerful glutathione suppository that offers greater absorption power than standard capsules or liquids. You get a maximum dosage of 500 gms of high-potency glutathione through this supplement, which is enough to improve your overall health substantially. Moreover, it uses a 100% probiotic blend that’s free of artificial additives and GMOs.
We found this suppository to be highly versatile in its functioning — it induces effective immune support against most types of infections, aids in digestion, and supports stomach balance. Moreover, the unique form of intake enables sustained glutathione release, maintaining peak blood glutathione levels for 5 to 6 hours. This allows the brain and body to absorb the antioxidant effectively, providing superior results.
This glutathione product might sometimes arrive in a partially molten form, so make sure you check the package carefully and report such an issue soon after.
The single biggest advantage of this rectal supplement is that it provides 40 to 50% more bioavailability, giving you faster and more pronounced results. Plus, the brand provides free shipping for the product, which adds to your savings.
How is glutathione produced in the body?
Firstly, know that glutathione is a tripeptide — a compound composed of three amino acids, viz. cysteine, glycerine, and glutamic acid. A significant portion of the glutathione in the body is generated from the ɑ-amino acid homocysteine.
At the start, homocysteine is converted to cysteine by the action of two enzymes. The latter phase comprises two other enzymatic reactions, which finally yield glutathione.
Do note that each enzyme used in the process requires specific nutrients to act the right way. These are known as cofactors and include glycine, Vitamin B6 and magnesium.
When does your body need a glutathione supplement?
The production of glutathione that we just talked about takes place in multiple steps, with each being quite delicate. As such, an increased concentration of toxins like peroxides, free radicals, heavy metals, and lipid peroxides can lead to major disruptions in the process.
Naturally, this will weaken the body’s ability to produce glutathione consistently. You’ll then need to restore the levels of this versatile antioxidant in the body.
How does glutathione work?
Commonly referred to as GHS, glutathione is an antioxidant that fights damage by free radicals and improves digestive health.
If the amount of free radicals in the body exceeds antioxidants, it will give rise to inflammation and several other health problems, including:
1. High blood pressure
3. Alzheimer’s Disease
So, maintaining the right glutathione levels in the body can help prevent such medical conditions in the long term by eliminating excess antioxidants.
Some research studies have also revealed that glutathione plays a key role in the creation and repair of DNA and proteins and can activate several enzymes. Moreover, it’s involved in effective nutrient breakdown for optimal absorption and digestion.
What are the benefits of glutathione?
Glutathione is undoubtedly among the world’s most powerful antioxidative supplements — it negates the destructive action of the highly damaging free radical molecules.
If you didn’t know this yet, let’s tell you that even the stress of intense exercise can enhance free radical activity in the body. That’s why glutathione supplements are especially beneficial for people regularly engaging in intense physical activities.
Let’s now take a closer look at the other benefits of this supplement:
a) Enhances insulin resistance
One of the many bodily changes associated with aging is the decrease of glutathione levels.
That said, some researchers have conducted studies on both animals and humans to understand the role of this antioxidant in insulin resistance and weight management. The findings showed that low levels of glutathione decelerate the fat-burning process in the body.
b) May reduce psoriasis
A 2013 study found that whey protein can be useful in treating psoriasis when taken orally. And this protein had been shown to raise glutathione levels previously. Do note that each participant was given 20 grams of the supplement for three months. At the same time, the researchers have stated that this subject needs to be studied more.
c) May reduce symptoms of Parkinson’s disease
You might already know that Parkinson’s disease impacts the body’s central nervous system and comes with symptoms like tremors. Although no medications or treatments have been found to cure the disease completely, an older study recorded some positive effects of an intravenous glutathione injection on some symptoms.
This report suggests that glutathione might help reduce such symptoms to improve the quality of life for Parkinson’s patients.
d) Treats cells damaged by fatty liver disease
Liver cells might die if the organ is deficient in antioxidants, including glutathione. This might lead to fatty liver disease in both alcoholic and non-alcoholic people. Research has revealed that glutathione may improve enzyme, protein, and bilirubin levels in the blood of patients facing this disease.
Notably, a specific study found the orally administered form to be especially useful for patients trying to enforce lifestyle changes proactively. Each patient was provided with 300 milligrams of glutathione each day for four months.
e) Helps fight autoimmune disease
The inflammation resulting from autoimmune diseases may enhance oxidative stress considerably. Some common autoimmune diseases include celiac disease, lupus, and rheumatoid arthritis. A study found that glutathione acts on oxidative stress by either reducing or stimulating your immunological response.
An autoimmune disease generally targets the mitochondria within specific cells, which glutathione can prevent by removing the damaging free radicals behind the disease.
f) May Treat peripheral artery disease
Glutathione supplementation is also regarded as beneficial for skin lightening — several glutathione-based skin whitening products are available on the market. But keep in mind that there’s little research to support this claim.
g) May reduce the impact of uncontrolled diabetes
High blood sugar levels are associated with lesser amounts of glutathione, which can cause tissue damage and oxidative stress in the long term.
Glycine and cysteine have been shown to boost glutathione levels, which lowers oxidative damage and stress in people suffering from uncontrolled diabetes. Notably, the participants in the study were placed on a dosage of 1.33 mmol/kg glycine and 0.81 mmol/kg of cysteine for two weeks.
Is it a good idea to supplement with building blocks of glutathione like N-acetyl-cysteine?
Though this compound is capable of producing cysteine, it may not function well if the body doesn’t have enough cofactor nutrients for the key enzymes to work. Even genetic variations can cause these enzymes to weaken considerably.
In comparison, going for a bioavailable form of glutathione will ensure you’re able to sustain, recycle, and reuse the compound effectively.
What should you look for in Glutathione supplements?
Though these supplements might appear the same at first, they’re different in many ways. That’s why you’ll have to watch out for some key factors to ensure you’re getting an option of high quality:
1. Ingredient Quality
Checking the quality of ingredients used is a primary lookout, as it will tell you a lot about the safety and effectiveness of the supplement.
We’d suggest checking the label to ensure the glutathione used is obtained from a non-GMO source. Make sure it isn’t made from soy lecithin, a GMO-rich compound. In comparison, non-GMO sunflower lecithin will be a much safer alternative.
Also, remember that glutathione is high in sulfur, which is why it can provide a sulfuric smell and taste to the compound. That’s why several manufacturers use sugar and other sweeteners to mask such a smell and taste. Additionally, ensure that it doesn’t contain any artificial sweeteners such as sucralose or aspartame.
In addition to including good-quality ingredients, the supplement should be such that it’s readily absorbed by your body. Going with liposomal glutathione is the best decision in this regard.
This variety is encapsulated with liposomal technology in small fat bubbles, a mechanism that protects the three amino acids making up the compound. As such, these components can easily pass through the intestine and into the bloodstream, enhancing glutathione bioavailability.
You’ll also need to check if the manufacturer is transparent in showcasing the supplement.
Ensure the website mentions the place of manufacture and the dosage and ingredients used. Also, it should have enough verified customer reviews to help you develop an idea about the effectiveness of the product — no information should appear to be hidden.
A glutathione supplement with a pure composition is likely to yield the most effective results. So, make sure to check whether the product you’re considering is free from fillers, flavorings, and preservatives. These are often added to the average supplements to make them look “more effective.”
A thorough check of the product label is another essential step in determining product quality. It will help you ascertain whether the supplement provides the active ingredient in a dosage large enough to fetch the desired results.
At the same time, keep in mind that there haven’t been any research studies on the ideal glutathione dosage to date. That’s why we’ve included higher and milder doses to suit the needs of all users.
Another point worth noting is that most brands nowadays provide images of the label on the product page. So, it won’t be difficult for you to check the essentials of the product composition.
6. Third-Party Testing
A brand that utilizes third-party testing to confirm the purity and potency of its supplements allows users to be more confident about their effectiveness. Otherwise, you’ll have to rely entirely on the brand’s claims and customer reviews.
Are glutathione supplements safe for everyone?
Although a few people have reported mild side effects from its regular consumption, Glutathione won’t have any massive impact on the body system. That’s why it’s safe for all users — even if you’re just looking to improve overall health and well-being, you can take such supplements without any worries.
Will glutathione have any adverse effects on the kidney?
Glutathione is unlikely to harm the kidney in any way. In fact, this organ requires a substantial amount of antioxidants to function properly — it often gets affected by free radicals and other damaging oxidants.
Does glutathione have any side effects?
Due to the lack of enough research on this antioxidant, there’s little information about the side effects associated with its use. But a few people reported that they experienced bloating and cramps after the first few days of use, while some others faced allergic skin reactions such as rashes.
What’s the recommended dosage for glutathione?
There’s not much scientific evidence with regard to determining the dosage, either. Some studies conducted to investigate specific health conditions have come up with various dosage recommendations.
The best dosage for a particular user will depend on various factors, including their sex, medical history, and age.
What are the natural sources of glutathione?
Know that glutathione is abundant in several vegetables and fruits. On the other hand, a study in the journal Nutrition and Cancer revealed that bread, cereals, and dairy products are typically low in this antioxidant. Vegetables and fruits contain moderate to high amounts of GSH, while meats prepared freshly have higher amounts.
Personal care products and dietary supplements containing glutathione are available across online retail platforms and in drugstores, vitamin shops, and natural-food stores.
Are glutathione injections safe, and do they work permanently?
Yes, glutathione injections are safe for the body as long as you’re using them in accordance with the prescribed guidelines in the healthcare field. We’d suggest hiring a healthcare professional to administer the injection as they’re well-versed with such rules.
Speaking of their effectiveness, glutathione injections are believed to function by bypassing the digestive system. That’s why they may facilitate efficient absorption of the antioxidant. Keep in mind that these injections mainly support healthy aging and speed up cell renewal. These beneficial effects can, in turn, boost energy levels and promote weight loss.
Can any medicinal drug interact with glutathione?
While this antioxidant is unlikely to react with most medications, you should avoid taking it while using chemotherapeutic and antipsychotic drugs.
Can you take glutathione with vitamins?
Yes, taking vitamins with glutathione supplements can, in fact, boost their effects by working with them synergistically within your body. A point worth noting here is that Vitamin C and B12 are the best options to pair up with your daily glutathione dosage.
While taking Vitamin B12 and the antioxidant can protect you from several deficiency diseases, Vitamin C maintains optimal glutathione levels in various tissues.
What’s the best time to take glutathione?
Glutathione is most effective when taken before eating or with an empty stomach, as that helps enhance the action of the antioxidant on the body.
Is it safe to take collagen while taking glutathione?
Yes, these supplements are safe to be taken together — no side effects have been recorded for such a dosage.
How does glutathione help in weight loss?
Taking glutathione regularly helps shift the body’s focus from fat production to the development of muscles. Also, it works to burn off more fat cells and removes toxins in the liver, which ultimately contribute to weight loss.
How much do glutathione supplements cost?
You get a wide range of products to choose from, meaning that there are options that suit different budget ranges. Also, keep in mind that the price will depend upon the glutathione delivery mechanism used and the form of the supplement.
For instance, an acetylated glutathione supplement such as the product from Dr. Amy Myers costs more than many others
You must’ve made your choice by now, so it’s time to order the best glutathione supplement for your needs. Trust us, you’ll witness the change soon.
Taking pure and all-natural glutathione will provide you with the right balance of digestion, vitality, and health to improve immunity and increase energy levels substantially.
Moreover, we’ve picked each product for our list based on in-depth research and inputs from long-term customers. Rest assured that all of them are equally reliable choices. Before we call it a day, let’s quickly take you through our favorites from the list.
The Bulletproof Glutathione Force Capsules is undoubtedly our top pick — its all-natural and sugar-free formulation promotes the fast and effective delivery of glutathione, providing the best possible long-term results.
However, if you require a formulation mainly focused on improving digestion, the Dr. Amy Myers Acetyl Glutathione Capsules will be the best choice.